Tuesday, January 26, 2010

Does Oral Cancer Look Like

different tracks: Stray? Mestizo? Please: Random Source 1

TRACCE DIVERSE: Randagio? Meticcio? Prego: Random Source 1


PREMESSA:

MAI NOTIZIA FU TANTO ALLARMANTE E VERA. CONSIGLIO A TUTTI DI LEGGERE IL POST TRATTO DAL BLOG 'TRACCE DIVERSE' LINKANDO DAL TITOLO STESSO PER IL REINDIRIZZAMENTO ALLA FONTE UFFICIALE O LEGGENDO QUANTO SEGUE A QUESTA PREFAZIONE.
SPACCATO SCONVOLGENTE, VERGOGNOSO, ORRIBILE. UN FILM CHE NESSUNO VOLEVA CREDERE COME VERO, MA DATI ALLA MANO, A QUANTO PARE LE PAURE DIVENGONO CERTEZZE INOSSIDABILI. MOLTE DOMANDE CHE SOLO POCHI MESI FA SEMBRAVANO SENZA UNA RISPOSTA ATTENDIBILE, DOPO AVER LETTO QUESTO ARTICOLO DIVENGONO OGGETTIVITA'. ORA NON RESTA CHE APRIRE GLI OCCHI E DECIDERE DAVVERO DA CHE PARTE STARE, PERCHE' L'APOCALISSE DEGLI ANIMALI HA AVUTO UN INIZIO IN SORDINA, UN COINVOLGIMENTO INSINCERO DI CHI HA SEMPRE VOLUTO FARSI DA PORTABANDIERA DI REALTA' MAI PORTATE ALLA LUCE NELLA LORO CONSISTENTE ESSENCE OF INTEREST FOR COMFORTABLE. Here, then, THE END. IS 'THE FINAL CHAPTER OF DRAMATIC AND WHO NOT ONLY HAS NEVER HAD VOICE, BUT ALSO BAD lawyers.

TIZIANA PAY


Stray? Mestizo? Please: Random Source 1

The American Physiological Society (APS), one of the largest American association for the promotion of biomedical research, is very worried, not without reason, and not now. The are taking away the most important intermediaries of the acquisition of dogs and cats by research institutes in price (relatively) small: the infamous B dealers.
for decades - and still today - research institutes have had their own farms and are also directly get the animals in kennels and shelters. But the greatest contribution has come and is supplier to professionals, the Department of Agriculture (USDA) divided by type of license granted in two categories: dealers Category A (Class A dealers), who breed dogs and select bred for research (purpose bred), and those of category B (class B dealers). IB dealers do not raise, but purchase by little animals, whatever their origin, age, health status, race and race (random source). They do it at other B dealers, at public shelters and private associations can also be managed at the respective associations at auction Home owners and breeders (all officially licensed). It also happens that they do - for free - in response to appeals for adoption online, quickly charging stray and wandering animals, disappearing from the gardens of the dog or cat home. In this they are helped by the equally notorious bunchers, the monopolists who work with their subcontractors.
and then sold to laboratories. By mutual benefit, because there's a big difference for some between the price paid initially and the fee charged for the sale to others in the final cost of a dog to a dog and B. Example date last year: a young dog of medium size costs 325-350 dollars if the lab is B, 600-900 dollari se è A. Ma se è A non deve avere più di sei mesi e mezzo, perché poi il suo costo sale di 4,10 dollari per ogni giorno di vita (National Academy of Sciences, Scientific and Humane Issues in the Use of Random Source Dogs and Cats in Research, p.81).


E allora? E allora, dice la National Academy of Sciences, “in un mondo ideale il costo non dovrebbe essere un fattore che influenzi le decisioni sulla ricerca, soprattutto su quella fatta su animali. Realisticamente, però, le risorse sono limitate e i ricercatori sono vincolati da preoccupazioni finanziarie. Così, per l’uso continuato di animali presi da venditori di classe B, che possono costare meno degli animali presi da venditori Class A, the cost is potentially a reason to be taken into account. The financial incentive to the use of animals taken from Class B dealers may or may not be substantial, depending on the circumstances. " Loud and clear.


Poorly controlled (and poorly controlled) by the USDA, the B dealers have long worked with profit. Over two hundred years 70-80 were in the States and research with animals A and B was at its maximum: in 1976 they were used a total of more than 210,000 dogs. Then the trend began to decline. Among other factors, perhaps but certainly were not significant determinants were the actions of animal rights groups. First of all, the Humane Society of United States (HSUS), which has a no-brainer than 11 million members and that while browsing to view on animal experimentation as many other associations (including those that antivivisection put it on the flag), in this case moved and is still moving.
Until something happened that caused a hurricane in the U.S. (and very happy that we wish for Europe, since this seems to be a script already known). In 2002, a voluntary association Last Chance for Animals in disguise you gave it in the stall of a large fortress-B dealer in Arkansas and for months, with a hidden camera, filmed more than seventy hours of abuse and much worse. Then came tutto al Procuratore generale. Il dealer fu condannato soltanto a una fortissima multa, ma perse la licenza. Il risultato più incisivo però fu sull’opinione pubblica e fu aiutato dall’uscita del documentario che presentò l’inchiesta, Dealing Dogs (http://www.hbo.com/docs/programs/dealingdogs/index.html).

Nel 2005 i cani usati divennero meno di 67.000, 38.000 dei quali erano di classe B. Da allora, molti Stati hanno vietato ai canili la vendita per la ricerca. I B dealers dediti a questo si sono ridotti in breve a meno di dieci, e non tutti sono fuori dai guai.



Perché questa lunga premessa? Perché è in questa situazione difficile che l’APS cominciò to run for cover with a series of appeals on the need for random source dogs and cats, random source, for biomedical research: In this 2006 article, looks a bit ', said to be very, very few, but essential to save lives human - it is said elsewhere - would otherwise be destroyed. And in an effort to bring up the assumption scientific style for us, under a light finally clear and cold, the catalog of reasons why, yes, dogs and cats are critical to any testing (by concealing the additional or essential, according to points of view: the price):



Why do we need dogs and cats home random?

animal models of disease offer an important means to find treatments for many diseases. A model of the disease should be an animal species with biological characteristics that make it susceptible to a condition similar to the disease being studied. Dogs and cats have served as models of many diseases, but have been particularly important for the study of diseases of the cardiovascular, digestive, musculoskeletal and neurological systems. In addition, dogs and cats are essential for veterinary research.
The vast majority of animals used for research - perhaps more than 95% - are specially bred mice and rats. Dogs and cats together represent a fraction of 1%. About two thirds of these dogs and cats are bred specifically for research. The others are non-purpose bred animals (reared specific purposes) or random source (the source random), also known as outbred (off farm) or mongrels (mixed race).

Traders Class A or breeders sell dogs and cats that are young and come from a limited gene pool. Factors such as age and mating inbreeding are important to consider in order to establish the research model. The typical features of specially bred dogs and cats are ideal for certain kinds of research, but not for others. For example, many diseases of the cardiovascular, digestive and musculoskeletal strike humans when they are older. Because the animals bred specifically for research are young, can not constitute good research models for some of these conditions. Genetic selection in inbreeding, which is the other aspect of animals specially bred, is a desirable feature for some studies, but can not be, because this selection can also produce separate characters that hinder research.

In comparison, dogs and cats are not bred with a view from different genetic backgrounds and represent a wide spectrum of ages. Although they form a tiny fraction of animals in research and medical education, random source dogs and cats giocano nondimeno un ruolo significativo.




Gli animali non allevati allo scopo sono importanti nella ricerca e nell’addestramento chirurgico cardiovascolare, perché la loro maggiore variabilità anatomica ha migliore corrispondenza con quella degli umani. Praticamente tutti i farmaci, i protocolli e tecniche chirurgiche per patologie cardiache sono stati sviluppati o testati su cani “random source”.



I cani e gatti non allevati allo scopo sono i modelli più adatti allo studio del diabete di tipo 2 e dell’insulino-resistenza. Queste condizioni, che insorgono naturalmente durante l’età avanzata degli umani, si verificano anche nell’età avanzata dogs and cats.



Their physiological similarities with humans make organs and cats not bred with a view valuable for research on diseases of the digestive tract, colitis, inflammatory bowel disease, gastro-esophageal reflux, swallowing disorders and nausea associated with cancer treatment.



Dogs and cats are genetically different and older needed to study Duchenne muscular and skeletal density associated with the decline of old age.


Cats have developed FIV (feline immunodeficiency virus) in a natural way (as opposed to artificially induced disease in cats reared order) are useful for both medical and veterinary research is on the retrovirus.

Without these animals, important research will suffer stagnation.


http://www.the-aps.org/pa/resources/bionews/classBdogs.htm


Keep in mind that all that we are referring to, digits, just about biomedical research in public institutions: the National Institutes of Health (NIH), officials from the Department of Health. Total silence on the rest, including the testing in the industries of course raises a lot of the statistical parameters (and let's leave here the relationships between well-known research institutes and industry).
However, the APS urges greater precision quando piange miseria in un comunicato del novembre 2009: per la ricerca c’è bisogno urgente e crescente di cani B “molto anziani, o con patologie preesistenti ed esposizione a virus, allergeni o parassiti”. Lo fa esprimendo – dal suo punto di vista – il suo totale appoggio al rapporto pubblicato in quei giorni dalla National Academy of Sciences (NAS) su richiesta del Congresso degli Stati Uniti.
Chiariamo, però. Il rapporto è redatto solo per rispondere a una domanda mirata: sono o no necessari i B dealers alla fornitura di animali random source per la ricerca? No, è l’ovvia risposta dopo anni di battage sull’argomento. Risposta che, sacrificando le pietre dello scandalo, soddisfa un bit 'all. And you can start over, because the NAS at this point suggests to the NIH to seek "alternative". For example, A could allow dealers to age a bit 'of their dogs (maybe coming meeting on the price) ... or the animals could be provided by "animal control facilities, from amateur breeders, owners from philanthropists who may make a gift science ... well, do the NIH an "extra effort" to identify new mechanisms in order to replace the animals so far supplied by B dealers. We would be more or less the previous situation, if there was a significant difference and brilliant: the abolition of the Ombudsman official and what constitutes as a loss of image ... and to declare as an expense. The rest, of course, is unchanged: as you wanted (including sales of B dealers to all other buyers other than the NIH). The successful impact on American public opinion happy to cleanse the conscience does not delete the registry canine private and chaotic, to put the easy sale ... if anything adds a detail: it seems that many people, horrified at the thought that your pet ends experimentation, rather than let go in kennels prefer to leave the street. Exactly.
All in all, the suggestion is a collection of nearby Canada, where there are no officially B dealers for research, but where the province of Ontario, which is the industrial model of the country, the law requires shelters to sell animals to laboratories. And in some respects is closer to a system of Europe, with its ancient wisdom may suggest many solutions.

http://www.newsweek.com/id/57139
American Physiological Society (APS):
http://www.the-aps.org/pa/resources/bionews/randomsource.htm
http:// www.the-aps.org/press/releases/09/44.htm
Humane Society of the United States (HSUS):
http://hsus.typepad.com/wayne/2007/06/b_dealers_a_cla.html
http: / / www.humanesociety.org/news/press_releases/2009/05/class_b_dealer_system_unnecessary_052909.html
http://hsus.typepad.com/wayne/2009/11/class-b-dealers.html
National Academy of Sciences:
http://www.nap.edu/catalog.php?record_id=12641

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